Institute for Ophthalmic Research Tübingen

Ute Mathis at work

Projects:

 

1. Co-localization of ZENK in the mouse retina with various neurotransmitters
1. Cellular distribution and visual regulation of TGF-beta2 in the fundal layers of the chicken


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Co-localization of ZENK in the mouse retina with various neurotransmitters

 

Ute Mathis studies the colocalization of the ZENK protein with retinal transmitters in the mouse.

Recent studies by Marita Feldkämper have suggested that the mRNA sequence for glucagon and the glucagon receptor can be isolated from the mouse retina. However, immunohistochemical staining of glucagon itself was not (yet?) successful.
This is in line with studies in other mammalian models, performed by Andy Fischer and Bill Stell (see "Collaborations"). It is possible that other neuropeptides, perhaps even metabolites of glucagon, may have taken over its signaling function.

Ute Mathis tries to localize potential candidates to the ZENK amacrine cells in the mouse retina.

 

 

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Cellular distribution and visual regulation of TGF-beta2 in the fundal layers of the chicken

 

TGF-beta2 is a well-known scleral growth modulator which also can be shown to change in concentration when growth is induced by diffusers or lenses in front of the eye.
TGF-beta2 has also been shown to change in the choroid, at least at the mRNA level, by Perikles Simon. However, the results are inconsistent in the literature regarding the retina.

Ute Mathis is studying cellular localization and visually-induced changes by immunofluorescent labelling in the chicken model.

 

Fig. 1: TGF-beta2 labelling in the chicken retina.

 

 
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© by Institute for Ophthalmic Research Tübingen, July 2008
Frank Schaeffel | Marita Feldkämper | Ute Mathis | Ruth Schippert | Erich Diedrich | Arne Ohlendorf
Juan Tabernero | Regan Ashby | Tudor Tepelus | Alexandra Penha | Eva Burkhardt | Gabi Kleine

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Department f. Augenheilkunde Tübingen Universitätsklinikum Tübingen Eberhard Karls Universität Tübingen Section of Neurobiology of the Eye Fig. 1 -click here-