Institute for Ophthalmic Research Tübingen

Arne Ohlendorf at work

Projects:

 

1. Time course and sign of defocus selectivity of contrast adaptation
2. How do observers deal with the angle kappa of a subjects when they estimate the direction of gaze?
3. Effects of peripheral defocus on accommodation


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Time course and sign of defocus selectivity of contrast adaptation

 

Arne Ohlendorf studies features of contrast adaptation. Contrast adaptation occurs if people (or animal models) are exposed to defocus, for instance because they wear inappropriate or no spectacle corrections.
If myopic subjects take off their glasses, their visual acuity is initially very poor but improves over a period of a few minutes. This improvement cannot be based on optical changes but results from changes in the processing of spatial features in the visual system. Probably, the retina changes contrast sensitivity for those spatial frequencies that are lacking in the retinal image or have only low contrast (defocus affects the higher spatial frequencies).

Arne Ohlendorf studies how long this process of contrast adaptation takes, how long it lasts, whether it is similar for defocus in positive or negative direction, at which spatial frequencies it occurs and whether it is different in the fovea and the periphery.

Different from most studies on contrast sensitivity and contrast adaptation, Arne Ohlendorf uses an inter-ocular contrast matching task (Figure 1).

Fig. 1: Set-up to measure the supra-threshold contrast sensitivity in the right eye relative to the left eye. The right eye was previously defocused by different trial lenses, while the subject watched a movie on a computer monitor at 1 m distance.

 

After 10 minutes, the supra-threshold contrast sensitivity was compared in both eyes, using the stimulus shown in Figure 2.

Fig. 2: Using the arrow keys of the key board, the subject had to match the subjective contrast of the sine wave grating seen by the left eye and the right eye. A cardboard divider prevented that an eye could see the target on the opposite side of the screen.

 

This study provided some interesting new results. Contrast adaptation lasted for about 3 minutes (Figure 3), and contrast adaptation could be induced by defocus only in the case of positive lenses.

The studies on contrast adaptation are important since contrast adaptation may be an error signal for emmetropization, causing the eye to grow differently. In addition, these studies may help to resolve the long-standing question as to how the retina can distinguish between positive and negative defocus (see Michaela Bitzer).

Fig. 3: Changes in supra-threshold contrast sensitivity, following 10 minutes of imposed defocus. Note that the right eye need less contrast to achieve a subjective match to the left eye and that this difference lasted for at least 3 minutes.

 

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How do observers deal with the angle kappa of a subjects when they estimate the direction of gaze?

 

Arne Ohlendorf also studies how subject evaluate the angle of kappa from outside. An interesting problem is how people can judge so well in which direction other people look and whether they fixate their eyes or look a few degrees aside. Since the pupil axis (which can be estimated by looking at a subjects eye from outside) and the fixation axis (passing through the fovea but cannot be seen from outside) differ by a few degrees in most subjects, it is difficult to judge were people look at. A comparison of both eyes may the key to this problem and, in fact, most people rapidly switch fixation from one eye to the other when they look in other's people faces. Preliminary results suggest that this happens just to eliminate the effects of kappa, which displays mirror symmetry in both eyes.

 

 

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Effects of peripheral defocus on accommodation

 

Finally, Arne Ohlendorf studies the effects of peripheral defocus on accommodation, with and without foveal stimulation.

 

 

 

 
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click on the images above to enlarge

 

 

 

 

© by Institute for Ophthalmic Research Tübingen, July 2008
Frank Schaeffel | Marita Feldkämper | Ute Mathis | Ruth Schippert | Erich Diedrich | Arne Ohlendorf
Juan Tabernero | Regan Ashby | Tudor Tepelus | Alexandra Penha | Eva Burkhardt | Gabi Kleine

History | Overview | Laboratory Goals | Technology Developments | Grants and Awards | Publications
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Department f. Augenheilkunde Tübingen Universitätsklinikum Tübingen Eberhard Karls Universität Tübingen Section of Neurobiology of the Eye Fig. 1 -click here- Fig. 2 -click here- Fig. 3 -click here-